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Implications of a New Explanation
for Anxiety & Depression


Kinkajou Kinkajou: In fact, what is the difference between someone having a grief reaction and someone who is depressed and who will not recover without treatment?

Dr Xxxxx DR Xxxxx : There is no answer to this in the standard medical model . There are no medical tests and the subjective judgment of the doctor is important in making this decision. So, some doctors will tell you that a depression is present and treat you, and some doctors will not diagnose depression and will not treat you.


DSM-4 and DSM-5:The official diagnostic manual of the American Psychiatric Association.


The Paill Spectrum model predicts that the person with minimal clinical signs of Paill Spectrum and the "more" normal blood tests , is probably undergoing a grief reaction , not a Paill Spectrum depressive illness. The criteria for diagnosis in the Paill Spectrum model of depression are much more objective. Doctors will more likely make the same diagnosis because the same symptoms, signs or blood test criteria of illness are present.

Blood testing Taking a blood test: the pathology test.

Dr Xxxxx DR Xxxxx : Many of these questions are very difficult to answer in the standard medical model that doctors use to understand depression. Often the answers or decisions come only with time.

The Paill Spectrum model is very definite about confirming the presence of depressive illness early, and the need for early effective treatment. 

Kinkajou Kinkajou : So, how do you treat Depression? :"-[

Dr Xxxxx DR Xxxxx : Treatment of Depression and Similar Illnesses

Treatment involves taking courses of antidepressant medications or drugs such as Zoloft (Sertraline), Avanza (mirtazapine), Cipramil (Citalopram), Effexor or Effexor XR (Venlafaxine), Aurorix (Moclobemide), Prozac (Fluoxetine), Aropax (Paroxetine), Tryptanol (Amitriptyline, often confused as amitriptyline / amitriptyline), , Sinequan (Doxepin) Edronax (Reboxetine), Luvox (Fluvoxamine).

These (medications) treatments relieve the symptoms of the illness and make people feel better.

The Paill Spectrum model suggests that symptomatic treatment is still important in some patients. However, long-term treatment using the Paill Spectrum model will make people better. Flare ups of depression are also rare when effective Paill Spectrum therapy has been instituted.

Irritability Anger An angry face: common in Paill Spectrum

Erasmus Profile Erasmus : Genesis & Treatment of the Depressive Disorders
The Paill Spectrum disease model as pioneered by Dr. Xxxxx, suggests that many depressions and depressive like illnesses are caused by infection with the Paill Spectrum organism. 

The presence of the causative infection in the model
Can be detected by specific blood tests,
Responds to specific antibiotics
Responds as well to specific nutritional therapies. 

It is critical to treat people with effective therapy, not just symptomatic antidepressant medication, or drugs.  Medicine for “symptoms” does not change the progress of the disease. Current thinking on depression relies on medications to control the symptoms of the disease, but relies on nature and time to do the healing.

Erasmus Profile Erasmus : The Paill Spectrum model of disease as developed by Dr. Xxxxx suggests that it is possible to alter the long term progression of a depressive illness with Paill Spectrum therapy. This is a very radically different stance to the current thinking of the medical profession.


Medical explanations for Depression.

Kinkajou Kinkajou : Some Depressions are due to genes, aren't they? Like Bipolar? 

Dr Xxxxx DR Xxxxx : Bipolar Disorder: Is it a Distinct Variety of Depressive Illness?

“Older” accepted medical opinion stated that bipolar depression or manic-depressive illness was a distinct genetically inherited disorder.  If you had the gene, you could likely get the disease.

Currently, the psychiatrists’ medical bible: the DSM IV TR does not state that this is true.  There does not seem to be a gene that causes bipolar depression. There does appear to be familial preponderance, (the condition runs in families). This suggests strongly that genes contribute susceptibility to the disease, but the DSM IV TR stops short of claiming a “gene” causes the illness.


Erasmus Profile Erasmus : The Paill Spectrum model of disease as developed by Dr. Xxxxx suggests that although bipolar disorder has an impressive sounding distinct medical definition, the practicalities of using the DSM IV TR definition, blur any possibilities of identifying a distinct medical bipolar syndrome that may have a genetic cause. The definition is too fuzzy to help identify people who may have a depressive illness that is triggered by a particular gene. Different doctors using the same criteria will come to different diagnoses. (Common themes or underlying causes of illness are therefore unable to be identified as sick people may or may not be identified by individual doctors).

Dr Xxxxx DR Xxxxx : DSM IV TR (DSM4 TR), describes a patient with bipolar depression as having a hypomanic or manic episode in their depression.  Hypomanic or manic events are essential to allow the diagnosis of Bipolar depression to be made. The key criteria for diagnosis of bipolar (namely, "What is a hypomanic event"?) are very loose and non-specific when one gets past all the impressive medical words.  Often doctors will describe anyone who is a bit irritable as hypomanic, so that subjective impressions of individual doctors are very likely to change the final diagnosis that the patient is given.

Many patients are often unable to be distinctly diagnosed for years, as all their illness symptoms have not developed.  (The standard medical model).

(The Paill Spectrum model of disease as developed by Dr. Xxxxx suggests that any patient who is a little bit irritable or impulsive with their depression, may often be diagnosed with bipolar depression by many doctors, rather than accepting that the irritability may be the result of a personality overlay or of Paill Spectrum infection.). 


The Paill Spectrum model predicts that irritability is likely to occur in the absence of a depression or in fact to precede the appearance of a depression by up to many years. The symptom is important in its own right. This is a predictable consequence of the Paill Spectrum disease theory.

The standard model of bipolar depressions does not suggest that mood volatility or irritability may lead to depression or other medical conditions at all.

The two models make quite different predictions as to the clinical course of the illnesses that people develop. The Paill Spectrum model in fact predicts that illness can be prevented if intervention is started early enough, before substantial damage is done.



Erasmus Profile Erasmus : The Paill Spectrum Disease Model as pioneered by Dr. Xxxxx, states that many patients with depressive illnesses including bipolar or dysthymia, are likely to have Paill Spectrum infection. (Dysthymia occurs where the person has mood swings only, rather than true depression or manic depression). Paill Spectrum infection is strongly influenced by genetically inherited, immune resistance factors.  There are a number of these factors, so the inheritance pattern would be expected to be complex or polygenic; exactly as the existing knowledge base on depressive illnesses, would suggest.

The Paill Spectrum model is consistent with the known objective facts that exiting medical knowledge has gleaned about depressions and related illnesses. 

Kinkajou Kinkajou : What are the Indications that Depressive Disorders are related to Paill Spectrum Illnesses?

Dr Xxxxx DR Xxxxx : Other symptoms of Paill Spectrum will often be found if searched for. 
Distinct blood test changes will also be found. 

Patients respond to both nutritional and antibiotic therapies.  Relying solely on antibiotic therapy is unwise with Paill Spectrum. 

The Paill Spectrum model of disease as developed by Dr. Xxxxx suggests that current psychiatric medications are excellent for symptomatic relief, in much the same way that Paracetamol (Panadol) gives relief from headaches or fever.  These medications make people feel better quickly.  They do not change the progress of the depressive illness.

Dr Xxxxx DR Xxxxx : SAD: Seasonal Affective Disorder
This condition occurs when there is a mood deterioration, (People begin to feel depressed), supposedly related to lack of light, usually associated with winter months. Treatment exposes the patient to increased light exposure for several hours per day. This is generally believed to have the effect of increasing brain chemicals with a resultant improvement in mood.

Interestingly, Paill Spectrum infections worsen late into the cooler months of the year and would also result in seasonal illness / mood changes. The question then is whether the people who are being treated would respond to other therapies such as the Paill Spectrum treatment protocol. Also whether the response to therapy the people are experiencing is due to light exposure in treatment or heat associated with light exposure, (directly or indirectly).

The Paill Spectrum disease model would predict that it is the heat that is more important in therapy, rather than just the light.
The Paill Spectrum disease model would also predict that there are other modalities of treatment that would make a difference to the progression of the disease. 

Kinkajou Kinkajou : Clinical Examples of Depressive Illness in Paill Spectrum
See our ENKPAILL.COM site
Case I (Paill anxiety & depression) ,
Case III (Paill mood swings) ,
Case V (Paill anger & memory loss),
Case VI (Paill anxiety)
for profiles of a sudden onset depression (and other symptoms) in a previously well patients.

As may be seen in the examples, depression often occurs in context of other psychiatric symptoms or illnesses. The Paill Spectrum model predicts that specific symptoms or signs of one illness, namely Paill Spectrum infection, occurs in many patients. This one illness (Paill Spectrum), is obvious from an early stage though the progression of illness symptoms will vary in individual people depending on the extent of the infection. 

Erasmus Profile Erasmus : Commentary on Patient’s Thinking on the Genesis of Depressions
It is surprising how many people blame current life circumstances for their depressive illness.  Dr. Xxxxx often hears people describe how grandma dying several months ago caused them to become ill.  Dr. Xxxxx states that his impression is that the key factor is probably the poor nutrition associated with the extra work or time commitment involved in caring for an ill loved one. This nutrition and self-care deterioration may then trigger the depressive illness. 

Often the symptoms of Paill Spectrum, cause personality and mood changes obvious to people living or working with the depression-affected person. 
These are often eventually fatal to relationships with the affected person eventually leading to a complex scenario of misery.

The Paill Spectrum affected person has an old unhappy memory from loss of a loved one & a new very unhappy memory from loss of a relationship with consequent grief.

(I.e. Paill Spectrum makes people depressed. When they feel depressed they focus on bad events on their lives and blame these for their circumstances. The Paill Spectrum infection also makes these people irritable so they are in fact irritable unpleasant and miserable people to live with. Quiet miserable people are generally tolerated better by their partners. Irritable miserable people are not. The depressed and irritable person usually treats their partner badly, rather than being more isolated and just treating themselves badly in a purely  “down” depressive illness. The existing relationship or marriage then breaks down, causing even more depression or mood changes.) 

(I.e. The partners of Paill Spectrum depressed individuals often walk out on their partners as they find them increasingly difficult to live with). : - [